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灭滴灵是硝基异嘧唑的一个衍生物。最早在1959年被用来治疗滴虫性阴道炎。本药对溶组织阿米巴、梨形鞭毛虫和梅毒螺旋体也有治疗作用。1962年Shinn首先发现它对厌氧菌的作用,用以治疗奋森氏咽峡炎。最近,本药己成为治疗厌氧感染的主要药物,并有可供静脉注射的制剂,用于严重感染的治疗。作用和主要药理特性: 灭滴灵分子为一不带电荷的小分子,在有氮还原酶的细菌体内,通过氮基还原作用而发挥生物活性。它在还原过程中可成一种
Metronidazole is a derivative of isosorbide. As early as 1959 was used to treat trichomonas vaginitis. The drug on the dissolved tissue amoeba, flagellifer and Treponema pallidum also have a therapeutic effect. Shinn first discovered its role as anaerobic bacteria in 1962 to treat Fenon’s angina. Recently, this medicine has become the main drug for treating anaerobic infections and is available as an intravenous preparation for the treatment of severe infections. Role and main pharmacological properties: metronidazole molecule is an uncharged small molecule, nitrogen-reductase bacteria play a biological activity through nitrogen-based reduction. It can be a kind of reduction in the process