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1966年 Ash 等曾报道,H_1—受体的作用可被传统的抗组胺药阻断,认为属第二型受体即H_2—受体。组胺广泛存在于胃肠、生殖、呼吸、心血管和神经系统的肥大细胞和血液白细胞上。已知,组胺的作用是参与速发型过敏反应,这种反应是可溶性抗原和组织中的抗体相互作用的结果。组胺双重抗体系统的理论促进了新的特异性 H_1—和 H_2—受体激动剂和阻断剂的
Ash et al. Reported in 1966 that the role of the H 1 -receptor can be blocked by conventional antihistamines, which is considered to be a type 2 receptor, namely H 2 -receptor. Histamine is widespread in the gastrointestinal, reproductive, respiratory, cardiovascular and nervous system of mast cells and blood leukocytes. Histamine is known to be involved in the immediate onset of hypersensitivity reactions as a result of the interaction of soluble antigens with antibodies in the tissues. The theory of histamine dual antibody systems has promoted the development of new specific H 1-and H 2 -receptor agonists and blockers