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纤维粘连蛋白存在核内结合区,其功能不甚清楚,文内用免疫组织化学方法对不明原因流产合体滋养细胞纤维粘连蛋白和死亡基因蛋白bak进行显微定位研究,结果显示:纤维粘连蛋白在合体滋养细胞核内呈免疫反应用性,bak在合体滋养细胞膜呈强阳性着色,提示纤维粘连蛋白在合体滋养细胞的核内结合与不明原因流产的调亡可能相关。
Fibronectin exists in the nuclear binding region, its function is not clear, the article by immunohistochemical staining of unseasonal abortion syncytiotrophoblast fibronectin and death gene protein bak micro localization study showed that: fibronectin in The syncytiotrophoblasts were immunologically reactive in the nucleus. Bak showed strong positive staining on the syncytiotrophoblastic membrane, suggesting that fibronectin may be associated with the apoptosis of unexplained abortion in the nucleus of syncytiotrophoblasts.