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慢性原发性肾小球疾病是对人民健康危害最大的肾脏病之一。其中尤以原发性肾炎占多数。系膜增殖性肾炎是我国肾炎中最常见的病理类型之一,据统计约占我国肾穿刺病人的半数光镜下表现为以系膜细胞和或系膜基质增生为主的病理改变,临床表现以持续性蛋白尿或反复发作性肉眼血尿为基本特征。近年来,对系膜增殖与微小病变和局灶性节段性硬化之间的关系的探讨日益受到国内外肾脏病学者的普遍重视。由于系膜增殖性肾炎在疾病发展过程中的特殊位置,以及在我国具有很高的发病率,研究该型肾炎的发病机理,观察其临床和病理的动态变化规律,评价中医药在该型肾炎中的疗效和可能机理,在我国更具有重要意义。因此我们自1990年起,采用近代名医张锡纯所拟“十全育真汤”加减组方并制成胶囊,对
Chronic primary glomerular disease is one of the kidney diseases that have the greatest harm to people’s health. Among them, primary nephritis is predominant. Mesangial proliferative nephritis is one of the most common pathological types in nephritis in China. According to statistics, approximately half of light microscopy of renal puncture patients in China is characterized by pathological changes mainly in mesangial cells and mesangial stromal hyperplasia. Persistent proteinuria or recurrent hematuria is the basic feature. In recent years, the relationship between mesangial proliferation and minimal changes and focal segmental sclerosis has been increasingly valued by scholars at home and abroad. Because of the special position of mesangial proliferative nephritis in the course of disease development and its high incidence in China, the pathogenesis of this type of nephritis is studied to observe the dynamic changes of its clinical and pathological features and evaluate the Chinese medicine in this type of nephritis. The curative effect and possible mechanism in Chinese are more important in our country. Therefore, since 1990, we have used the modern famous doctor Zhang Xichun’s proposed “Shiquan Yuzhen Decoction” to add and subtract formulae and make capsules.