论文部分内容阅读
目的 研究常用抗帕金森药多巴胺受体激动剂吡贝地尔(泰舒达)对脑多巴胺转运体的影响。方法立体定位右侧纹状体注射6-羟多巴胺制备偏侧帕金森病大鼠模型,模型成功后予吡贝地尔灌胃治疗[30 mg/(kg·d)]5周。分4组(正常组、帕金森病模型大鼠组、帕金森病模型大鼠经吡贝地尔治疗组、帕金森病模型大鼠未治疗组)行大鼠脑多巴胺转运体田99Tcm-TRODAT-1放射自显影。图像分析得到纹状体与小腑的平均光密度值,计算并比较各组左、右两侧脑多巴胺转运体的特异性放射性摄取比值(纹状体/小脑-1)的变化。结果 正常大鼠脑多巴胺转运体对99Tcm-TRODAT-1的特异性放射性摄取比值左、右两侧无显著性差异;成为帕金森病模型后,两侧比值较正常均降低,右侧(损毁侧)降低叫显。未治疗组帕金森病模型大鼠双侧比值均较刚成模型时明显升高;经吡贝地尔治疗后,双侧比值均较未治疗组显降低,右侧(损毁侧)降低更甚。结论 长期吡贝地尔(泰舒达)治疗可能会使帕金森病模型大鼠脑多巴胺转运体的数量减少。
Objective To study the effects of commonly used anti-Parkinson’s dopamine receptor agonist Piracetam on brain dopamine transporter. Methods The right lateral striatum was injected with 6-hydroxydopamine to prepare a rat model of hemiparkinsonism. The model was successfully treated with piribedil [30 mg / (kg · d)] for 5 weeks. The rats were divided into 4 groups (normal group, model rats of Parkinson’s disease, model rats of Parkinson’s disease treated with piribedil and untreated group of model rats of Parkinson’s disease). The dopamine transporter 99Tcm-TRODAT -1 autoradiography. The average optical density values of striatum and small intestine were obtained by image analysis, and the changes of specific radioactivity uptake (striatum / cerebellum-1) of left and right brain dopamine transporters in each group were calculated and compared. Results There was no significant difference in the specific radioactivity uptake of 99Tcm-TRODAT-1 between normal rat brain dopamine transporter and the right and left sides Reduce the call was significant. Bilateral ratio of untreated Parkinson’s disease model rats were significantly higher than that of the model rats. After treatment with piribedil, the bilateral ratios were significantly lower than those of the untreated group, and the right side (lesion side) was even worse . Conclusion Long-term treatment with piribedil may reduce the number of dopaminergic dopaminergic neurons in the Parkinson’s disease model rats.