对帕金森病患者运动辅助区rTMS的调节治疗诱发的运动障碍

• 作 者: Koch G. Brusa L. Caltagirone C. 王孝文
• 机 构: Dr.Fondazione Santa Lucia IRCCS Laboratorio di Neurologia Clinica e Comportamentale Via Ardeatina 3
• 出 处: 世界核心医学期刊文摘(神经病学分册)
• 发表日期: 2005年12期
• 关键词: 帕金森病 运动障碍 左旋多巴 辅助运动 重复经颅磁刺激 神经机制 治疗作用 阿朴吗啡 药物诱导 频率

The neural mechanisms and circuitry involved in levodopainduced dyskinesia are unclear. Using repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA) in a group of patients with advanced Parkinson disease, the authors investigated whether modulation of SMA excitability may result in a modification of a dyskinetic state induced by continuous apomorphine infusion. rTMS at 1 Hz was observed to markedly reduce drug-induced dyskinesias, whereas 5-Hz rTMS induced a slight but not significant increase.

The neural mechanisms and circuitry involved in levodopainduced dyskinesia are unclear. Using repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA) in a group of patients with advanced Parkinson disease, the authors investigated whether modulation of SMA excitability may result in a modification of a dyskinetic state by continuous apomorphine infusion. rTMS at 1 Hz was observed to markedly reduce drug-induced dyskinesias, while 5-Hz rTMS induced a slight but not significant increase.