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胆道闭锁(BA)是导致小儿梗阻性黄疸的常见疾病之一。目前病因仍不清楚,预后较差。近2 a来,BA病因及机制的研究重点是基因突变、体液免疫和病毒感染;粪便彩色卡片在早期筛查方面表现出良好的前景;Kasai手术仍为早期治疗BA的首选,目前Kasai手术方式的进步主要体现在腹腔镜手术和机器人手术,而术后激素的应用仍存在较大争议;肝移植已成为治疗BA、胆汁性肝硬化的唯一手段。现就该病的病因、诊断及治疗进展作一简要综述。
Biliary atresia (BA) is one of the common diseases that cause obstructive jaundice in children. The cause is still not clear, the prognosis is poor. The past two years, BA etiology and mechanism of the study focus on gene mutations, humoral immunity and viral infection; stool color cards in the early screening showed good prospects; Kasai surgery is still the first choice for the treatment of BA, the current Kasai operation The progress is mainly reflected in laparoscopic surgery and robotic surgery, and the postoperative application of hormones is still more controversial; liver transplantation has become the only means of treatment of BA, biliary cirrhosis. Now on the etiology, diagnosis and treatment of a brief review.