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本文报道在扶绥县肝癌高低发区儿童的抗-HBc IgM检测,共检测345人,抗-HBc IgM阳性率为11.0%,其中肝癌高低发区分别为10.3%及11.6%,两地无明显差别。性别年龄分布,男女无明显差别。两地皆以9～12岁年龄组抗-HBc IgM阳性率最高,达20.0%左右,这些阳性儿童其抗-HBc IgM多为高滴度,且有肝功能异常,提示这很可能是水平传播的急性乙型肝炎。结合抗-HBc,HBsAg,肝功能三项指标与抗-HBc IgM检测结果比较,两地抗-HBc及HBsAg阳性者的抗-HBc IgM阳性率最高,但肝功能异常率更高,两地分别为53.2%及31.2%,相差非常显著,同时HBsAg阴性者也有较高的肝功能异常率,两地分别为50.0%及30.8%。提示肝癌高低发区除了HBV感染影响肝功能异常者外,还可能有其他损伤肝脏的有害物质存在,特别在肝癌高发区。值得进一步研究。
This paper reports the detection of anti-HBc IgM in 345 children with HCC in Fusui county. The positive rate of anti-HBc IgM was 11.0%, of which 10.3% and 11.6% difference. Sex Age distribution, no significant difference between men and women. The positive rate of anti-HBc IgM was highest in both age groups of 9-12 years old, reaching about 20.0%. Most of these positive children had high titers of anti-HBc IgM and had abnormal hepatic function, suggesting that this was probably horizontal transmission Acute Hepatitis B Anti-HBc, HBsAg, liver function combined with anti-HBc IgM test results showed that anti-HBc and HBsAg-positive patients in both anti-HBc IgM positive rate of the highest, but a higher rate of abnormal liver function, the two were 53.2% and 31.2% respectively. The difference between the two groups was also significant (50.0% and 30.8% respectively). Hint areas of high and low incidence of liver cancer in addition to HBV infection affect liver dysfunction, there may be other harmful substances exist in the liver, especially in areas with high incidence of liver cancer. Worth further study.