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目的 :研究转移相关基因1(metastasis associated gene 1,MTA1)蛋白在子宫颈(以下简称宫颈)不同病变组织中的表达情况及其临床意义。方法:应用SP免疫组织化学染色法检测40例宫颈癌、45例宫颈上皮内瘤变(cervical intraepithelial neoplasias,CIN)、30例慢性宫颈炎和20例正常宫颈组织的石蜡标本中MTA1蛋白的表达情况,并对其表达水平与宫颈癌的病理类型、分化程度、临床分期及是否有淋巴结转移等生物学行为间的相关性进行分析。结果:MTA1的高表达率在正常宫颈组(0)、CIN组(57.78%)、宫颈癌组(87.50%)间的比较,差异有统计学意义(P<0.05),而慢性宫颈炎组(10%)与正常宫颈组相比,MTA1高表达率差异无统计学意义(P>0.05)。慢性宫颈炎组与CIN组、宫颈癌组3组间两两相比,MTA1高表达率差异均具有统计学意义(P<0.05)。MTA1的高表达率在鳞状上皮内低度病变(low grade squamous intraepithelial lesion,LSIL)、鳞状上皮内高度病变(high grade squamous intraepithelial lesion,HSIL)、宫颈鳞癌3组间比较,也具有显著差异(P<0.05)。MTA1的高表达率与病理类型无关(P>0.05),而与宫颈癌的分化程度、淋巴结转移及临床分期有关(P<0.05)。结论:MTA1在正常宫颈组织及慢性宫颈炎组织中呈低表达,而MTA1在CIN及宫颈癌中呈现高表达,其高表达率与宫颈癌的分化程度、淋巴结转移及临床分期有关。
Objective: To investigate the expression of metastasis associated gene 1 (MTA1) in different pathological tissues of the cervix (hereinafter referred to as the cervix) and its clinical significance. Methods: SP immunohistochemical staining was used to detect the expression of MTA1 protein in 40 cases of cervical cancer, 45 cases of cervical intraepithelial neoplasias (CIN), 30 cases of chronic cervicitis and 20 cases of normal cervix , And analyzed its correlation with the biological behavior of cervical cancer such as pathological type, differentiation degree, clinical stage and lymph node metastasis. Results: The high expression rate of MTA1 was significantly different between normal cervix group (0), CIN group (57.78%) and cervical cancer group (87.50%) (P <0.05) 10%) compared with normal cervical group, the high expression rate of MTA1 was no significant difference (P> 0.05). There were significant differences in the high expression rate of MTA1 between chronic cervicitis group and CIN group and cervical cancer group in any two groups (P <0.05). The high expression rate of MTA1 was also significantly different among the three groups in low grade squamous intraepithelial lesion (LSIL), high grade squamous intraepithelial lesion (HSIL) and cervical squamous cell carcinoma Difference (P <0.05). The high expression rate of MTA1 was not related to the pathological type (P> 0.05), but correlated with the differentiation of cervical cancer, lymph node metastasis and clinical stage (P <0.05). Conclusions: MTA1 is low expressed in normal cervical tissue and chronic cervicitis tissues, while MTA1 is highly expressed in CIN and cervical cancer. The high expression rate of MTA1 is related to the differentiation, lymph node metastasis and clinical stage of cervical cancer.