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目的研究患者血清C反应蛋白(CRP)值的高低与脑梗死诊治之间的关系,探索CRP在脑梗死治疗中的临床价值及意义。方法分析某院内科初次明确诊断为脑梗死的112例患者,测定其发病d3血清CRP水平,根据CRP水平,将患者分为低CRP组和高CRP组,入院后对所有患者进行神经功能缺失评分,并计算发病后3月的残疾率、死亡率。测量(或计算)两组患者颈动脉粥样硬化各相关指标。结果低CRP组患者占42.86%,高CRP组患者占57.14%。低CRP组患者的神经功能缺失评分、残疾率及死亡率分别为(10.48±3.96)分、37.50%、8.33%,明显低于高CRP组的(19.14±9.01)分、73.44%、23.44%;低CRP组患者颈总动脉内膜中层厚度(IMT[Microsoft1])、颈内动脉IMT、颈动脉斑块发生率分别为(1.17±0.14)mm、(1.07±0.10)mm、54.17%,明显低于高CRP组患者的(1.29±0.10)mm、(1.21±0.09)mm、85.94%;低CRP组共发现斑块101处,高CRP组共发现斑块219处,低CRP组颈动脉粥样硬化斑块患者稳定性斑块构成比57.43%,明显高于高CRP组的38.81%,差异有统计学意义(P﹤0.05)。结论应加强脑梗死患者CRP值的监测工作,以有效评价脑梗死患者病情,积极进行相应的治疗。
Objective To study the relationship between the level of serum C-reactive protein (CRP) and the diagnosis and treatment of cerebral infarction and to explore the clinical value and significance of CRP in the treatment of cerebral infarction. Methods One hundred and twelve patients diagnosed as cerebral infarction for the first time in a hospital were analyzed. CRP level in d3 serum was determined. According to CRP level, patients were divided into low CRP group and high CRP group. All patients were evaluated for neurological deficit score , And calculate the morbidity and mortality in March after the onset of illness. Measurement (or calculation) of the two groups of patients with carotid atherosclerosis related indicators. Results Low-CRP patients accounted for 42.86%, high CRP patients accounted for 57.14%. The scores of neurological deficit, disability and mortality in low CRP group were (10.48 ± 3.96), 37.50% and 8.33%, which were significantly lower than those in high CRP group (19.14 ± 9.01, 73.44 and 23.44% respectively). The carotid artery intima-media thickness (IMT [Microsoft1]), carotid artery IMT and carotid artery plaque in patients with low CRP were (1.17 ± 0.14) mm, (1.07 ± 0.10) mm and 54.17% (1.29 ± 0.10) mm, (1.21 ± 0.09) mm, 85.94% in the patients with high CRP. There were 101 plaques in the low CRP group and 219 plaques in the high CRP group. The carotid atherosclerosis The plaque stability ratio of patients with plaque was 57.43%, which was significantly higher than that of the high CRP group (38.81%), the difference was statistically significant (P <0.05). Conclusion The monitoring of CRP in patients with cerebral infarction should be strengthened in order to effectively evaluate the condition of patients with cerebral infarction and actively carry out the corresponding treatment.