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目的 探讨偏头痛患者发作间期颅内动脉血流速度、血浆一氧化氮（ＮＯ）含量变化及其临床意义。方法 采用硝酸还原酶法对５０例偏头痛患者和４０ 名健康体检者应用彩色经颅多普勒超声（ＴＣＤ）检测及血浆ＮＯ含量测定，观察ＮＯ含量与偏头痛患者病程长短、颅内动脉血流速度及血流速度增快血管支数之间的关系。结果 偏头痛组血浆ＮＯ 含量明显低于对照组，分别为５６．２５±２２．２１ μｍ ｏｌ／Ｌ、７４．５２±２０．１３μｍ ｏｌ／Ｌ（Ｐ＜ ０．０１）。这种变化与颅内动脉血流速度及血流速度增快血管的支数有关，而与患者病程无关。结论 偏头痛患者发作间期颅内动脉仍处于收缩状态，其病理生理过程与扩血管因子ＮＯ有密切关系。临床上动态监测患者血浆ＮＯ 含量，可作为临床判断偏头痛轻重程度的一个参考指标。
Objective To investigate the changes of intracranial arterial blood flow velocity and plasma nitric oxide (NO) level in patients with migraine and its clinical significance. Methods The color Doppler ultrasound (TCD) and plasma NO levels were measured in 50 migraineurs and 40 healthy volunteers by nitric acid reductase method. The effects of nitric oxide (NO) content and duration of migraine were observed. The intracranial arterial blood The relationship between flow velocity and blood flow velocity increased blood vessel count. Results The content of NO in the migraine group was significantly lower than that in the control group (56.25 ± 22.21 μmol / L, 74.52 ± 20.13 μmol / L, P <0.01). This change and intracranial arterial blood flow velocity and blood flow velocity increased blood vessel count, and has nothing to do with the patient’s course. Conclusion The intercranial intracranial arteries in patients with migraine are still in contractile state. The pathophysiological process is closely related to the vasodilator NO. The dynamic monitoring of plasma NO level in clinic can be used as a reference index to judge the severity of migraine.