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该文旨在系统回顾多西环素(DS)硬化治疗儿童头颈部淋巴管畸形的疗效,并对患者因素与治疗成功的相关性进行评估。检索Pub 、EMBASE和Ovid数据库(1995-2014),对接受DS的头颈部淋巴管畸形患儿进行分析。影像学评估体积减小50%及临床症状缓解作为治疗成功的标准。结果:符合纳入标准的38例患儿中,治疗剂量多以10mg/m L为主,最高浓度为20mg/mL。32(84.2%)例患儿治疗成功,23(60.5%)例仅治疗1个疗程。平均随访9.7个月。年
The aim of this review was to systematically review the efficacy of doxycycline (DS) sclerotherapy in the treatment of lymphatic vessel malformations in the head and neck of children and evaluate the association between patient factors and treatment success. Pub, EMBASE and Ovid databases (1995-2014) were retrieved for analysis of children with head and neck lymphangitic deformities who underwent DS. Imaging assessment of 50% reduction in volume and clinical symptom relief as the standard of treatment success. Results: Among the 38 children who met the inclusion criteria, the most effective dose was 10 mg / m L and the highest concentration was 20 mg / mL. 32 (84.2%) cases of successful treatment of children, 23 (60.5%) treated only one course of treatment. The average follow-up of 9.7 months. year