庆大霉素发酵生产不用食油

• 机 构: 成都军区总医院药厂,
• 出 处: 人民军医
• 发表日期: 1978年01期
• 关键词: 消沫剂 碳源 抗菌素 操作规程 油提 发酵罐 庆大霉素 体积 效价单位 生产过程

抗菌素生产过程中,一般都用食用油作为消沫剂和基础碳源。1973年2月,我们学习上海制药四厂在发酵罐安装消沫桨后,减少了部分消沫用油。经过实践,认为消沫桨只能在一定体积范围内起到消沫作用。于是又调整工艺,改为投料时采用小体积进、少量多次补入的办法,严格操作规程,完全取消了消沫用油,同时为不用或少用基础油提

Antibiotic production process, the general use of edible oil as defoaming agent and basic carbon source. February 1973, we learned Shanghai Pharmaceutical Factory installed in the fermentation tank defoaming paddle, reducing some of the foam consumption. After practice, that defoaming paddle can only play a role in defoaming volume within a certain volume. Then adjust the process, instead of feeding a small volume into a small amount of a few times to fill in the way, strict rules and regulations, the complete elimination of the foam oil, at the same time, with or without base oil