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进一步研究评价各种化学因素不良作用的最敏感的指标,是环境卫生学十分现实的任务。研究机体各种反应的一般规律,包括某些生物学作用(肝毒、神经毒和性腺毒作用)的代谢过程是很有前途的。选出最主要的生物学评价指标作为补充实验也是很有必要的。用这些实验来确定环境污染引起的早期健康状况改变(病前改变)。鉴于唾液糖蛋白(Sialoglycoprotein)对生物膜结构与稳定性起作用,及其参与细胞间的相互作用和机体对化学因素作用的防御反应,本文研究了这些高生物活性物质代谢变化的意义。考虑到溶酶体水解酶参与细胞分化、免疫和调节环境因素对膜损伤的生化适应机制,以及内质网参与对外源性化学物质(Xen0bioti-
Further research on the most sensitive indicators for assessing the adverse effects of various chemical agents is a very realistic task for environmental hygiene. It is promising to study the general laws of various responses in the body, including the metabolic processes of certain biological roles (hepatotoxicity, neurotoxicity and gonadal toxicity). It is also necessary to choose the most important biological evaluation index as supplementary experiment. These experiments were used to identify changes in early health conditions (pre-morbidity changes) caused by environmental pollution. In view of the role of Sialoglycoprotein in biofilm structure and stability, and its involvement in cell-cell interactions and the body’s defense response to chemical effects, the significance of metabolic changes in these highly biologically active substances has been investigated. Considering that lysosomal hydrolase participates in the biochemical adaptation mechanism of membrane damage induced by cell differentiation, immunity and environmental regulation, as well as the involvement of endoplasmic reticulum in exogenous chemical substances (Xenobioti-