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目的对氯吡格雷治疗在冠心病患者的残余血小板高反应性的影响因素予以探讨。方法依据患者残余血小板高反应性,将200例患者分为对照组(即高反应组110例)、观察组(即非高反应组90例)。通过查询病历法,整合患者的一般资料。结果 BMI、糖尿病合并的情况、冠心病类型、血糖发生病变≥3支这几方面是冠心病患者发生残余血小板高反应性的影响因素。也有研究表示,糖尿病是冠心病产生残余血小板高反应性的因素,与血小板等有关。按照糖尿病是否合并的水平和HbA1c的水平将一部分患者分成A、B、C 3组,结果显示残余血小板高反应性与HbA1c呈正相关的关系。最终导致血小板活化。结论血小板高反应性和冠状动脉粥样硬化的发生、病变大小是有关系的。
Objective To investigate the influential factors of residual platelet hyperresponsiveness in patients with coronary heart disease treated with clopidogrel. Methods According to the patients with residual platelet hyperreactivity, 200 patients were divided into control group (ie, 110 cases of high response group) and observation group (90 cases of non-high response group). Through the inquiry medical record method, the general information of the patient is integrated. Results BMI, diabetes mellitus, coronary heart disease, blood glucose ≥ 3 lesions in these aspects of coronary heart disease patients with residual platelet hyperresponsiveness. There are also studies have shown that diabetes is a cause of coronary heart disease residual platelet hyperresponsiveness factors, and platelets and so on. According to the degree of diabetes mellitus and the level of HbA1c, some patients were divided into groups A, B and C. The results showed that there was a positive correlation between residual platelet hyperresponsiveness and HbA1c. Eventually lead to platelet activation. Conclusion Platelet hyperreactivity and coronary atherosclerosis occur, the size of the lesion is related.