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目的探讨纳洛酮联合醒脑静治疗急性乙醇中毒的临床效果。方法选取我院2015年1月-2016年1月收治的100例急性乙醇中毒患者,将患者随机分成对照组和实验组,所有患者在给予补液、利尿及维生素补充等治疗的基础上,对照组给予纳洛酮静脉推注,实验组给予纳洛酮和醒脑静联合静脉推注,对比两组患者的症状减轻时间,完全清醒时间及疗效。结果对于共济失调期患者,实验组与对照组在症状减轻时间及完全清醒时间上的差别没有统计学意义(P>0.05);对于昏迷期患者,实验组的症状减轻时间及完全清醒时间明显短于对照组,且差异有统计学意义(P<0.05);两组患者治疗有效率的比较,差异有统计学意义(χ~2=6.6,P<0.05)。结论纳洛酮联合醒脑静用于急性乙醇中毒的治疗,临床效果显著,症状减轻时间短,无明显毒副作用,值得临床推广。
Objective To investigate the clinical effect of naloxone and xingnaojing in treating acute alcoholism. Methods A total of 100 patients with acute alcoholism admitted in our hospital from January 2015 to January 2016 were selected and randomly divided into control group and experimental group. All patients were treated with rehydration, diuresis and vitamin supplementation. The control group Naloxone given intravenous injection, the experimental group was given naloxone and Xingnao Jing intravenous injection, compared with the two groups of patients to reduce the symptoms, complete recovery time and efficacy. Results For ataxia patients, there was no significant difference between the experimental group and the control group in symptom relieving time and complete awake time (P> 0.05); for patients in coma, the relief time and complete awake time of the experimental group were significantly Shorter than the control group (P <0.05). There was significant difference between the two groups in the treatment efficiency (χ ~ 2 = 6.6, P <0.05). Conclusion naloxone combined with xingnaojing for the treatment of acute alcoholism, the clinical effect was significant, shortened symptoms, no obvious side effects, is worthy of clinical promotion.