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目的了解浙江省台州地区妇女感染人乳头瘤病毒(HPV)和年龄分布,以及各亚型与宫颈病变的关系。方法采用聚合酶链反应扩增结合DNA芯片反向点杂交技术,对来浙江省台州市中心医院妇科就诊的2913例患者进行生殖道HPV亚型检测。结果HPV总感染率35.08%,检出前5位依次为HPV16(占7.76%)、HPV11(占7.38%)、HPV52(占6.25%)、HPV33(占4.81%)、HPV58(占4.50%)。结论台州地区妇女生殖道HPV人群感染年龄主要分布在40岁以下,以高危型为主,与宫颈病变的发生密切相关。
Objective To investigate the prevalence of human papillomavirus (HPV) infection and its age distribution in Taizhou, Zhejiang Province, and the relationship between subtypes and cervical lesions. Methods Polymerase chain reaction amplification combined with DNA chip reverse dot blot technique was used to detect the genital tract HPV subtypes in 2913 patients who came to the gynecological department of Central Hospital of Taizhou City, Zhejiang Province. Results The total HPV infection rate was 35.08%, followed by HPV16 (7.76%), HPV11 (7.38%), HPV52 (6.25%), HPV33 (4.81%) and HPV58 (4.50%). Conclusion The prevalence of HPV infection in women genital tract in Taizhou is mainly distributed under the age of 40, mainly in high-risk type and closely related to the occurrence of cervical lesions.