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用血小板凝血酶敏感素（ＴＳＰ）、血小板膜糖蛋白（ＧＰ）Ⅱｂ／Ⅲａ复合物和ＩｇＧ单克隆抗体，用碱性磷酸酶－抗碱性磷酸酶染色法对７例正常儿童和２７例特发性血小板减少性紫癜（ＩＴＰ）患儿骨髓巨核细胞进行研究。结果发现：正常儿童巨核细胞ＴＳＰ和ＧＰⅡｂ／Ⅲａ含量与细胞成熟程度成正比；２７例患儿的巨核细胞ＧＰⅡｂ／Ⅲａ含量均降低，２３例ＴＳＰ含量减少，１２例巨核细胞上ＩｇＧ含量增高，且ＩｇＧ增高与ＴＳＰ降低有一定关系。提示，在儿童ＩＴＰ的发病过程中，不仅存在血小板破坏增加，而且巨核细胞的成熟受阻，这种受阻可能是血小板抗体作用于巨核细胞的结果。
TSP, GP Ⅱb / Ⅲa complex and IgG monoclonal antibody were used to detect the levels of TSP, IgG and AKP in seven normal children and 27 special subjects Bone marrow megakaryocytes from children with idiopathic thrombocytopenic purpura (ITP) were studied. The results showed that the content of TSP and GPⅡb / Ⅲa in normal children’s megakaryocytes was directly proportional to the degree of cell maturation. The content of GPⅡb / Ⅲa in megakaryocytes was decreased in 27 children, the content of TSP was decreased in 23 children, and the content of IgG in 12 cases of megakaryocytes was increased Increased IgG and reduce the TSP have a certain relationship. Tip, in the pathogenesis of childhood ITP, not only the existence of increased platelet destruction, and the maturation of megakaryocytes blocked, this blockage may be the platelet antibody acting on megakaryocytes results.