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用高分辩电泳法对获得性免疫缺陷综合征(acquired immunodeficiency syadrome,AIDS)患者的血清标本作了分析。发现27例Kaposi氏肉瘤患者中的24例和15例条件致病性感染(opportu nist infection,OI)中的2例的血清,单克隆和寡克隆免疫球蛋白(oligoclonal immunoglobulins)的出现率高。单克隆蛋白带的存在与患者是否有过OI无关。这些发现说明,伴有Kaposi氏肉瘤的AIDS患者中单克隆或寡克隆B—细胞活化的发生率要高得多。从而提示,在AIDS患者的B—细胞和内皮细胞恶性或假恶性增殖当中,相似的机制可能起着作用。获得性免疫缺陷综合征(AIDS)是近来报道的一种病,它由严重的条件致病性感染(opportunistinfection,OI)、Kaposi氏肉瘤(KS)的发生,淋巴腺肿瘤和细胞免疫体系的基本功能丧失等组成。最近已经报道了这些病人多克隆B—淋巴细胞活化作用和B-细胞免疫调节异常。我们用高分辩电泳法证明了那些存在KS的AIDS患者,除了有以前报道过的多克隆B—细胞活化作用之外,单克隆或寡克隆B—细胞还有变化。
Serum samples of patients with acquired immunodeficiency syadrome (AIDS) were analyzed by high-resolution electrophoresis. Serum, monoclonal and oligoclonal immunoglobulins in 24 of 27 Kaposi’s sarcomas and 15 of 15 opportunistic nosocomial infections (OI) were found to be high in incidence. The presence of monoclonal protein bands has nothing to do with whether patients have OI. These findings indicate that the incidence of monoclonal or oligoclonal B-cell activation in AIDS patients with Kaposi’s sarcoma is much higher. This suggests that a similar mechanism may play a role in the malignant or pseudo- malignant proliferation of B-cells and endothelial cells in AIDS patients. Acquired immunodeficiency syndrome (AIDS) is a recently reported disease that is caused by severe opportunistic infections (OIs), Kaposi’s sarcoma (KS), basic lymphatic tumors and cellular immune systems Loss of function and other components. These patients have recently reported polyclonal B-lymphocyte activation and abnormal B-cell immune regulation. We used high-resolution electrophoresis to demonstrate that those with KS-associated AIDS patients had changes in either monoclonal or oligoclonal B-cells in addition to the previously reported polyclonal B-cell activation.