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目的:探讨多巴丝肼与小剂量的多奈哌齐联合治疗帕金森病的疗效及其对认知功能和抑郁情绪的影响。方法:从阳江市中医医院2014年1月至2017年1月收治的帕金森病患者中选取80例作为研究对象,以随机分组方式分为观察组40例,对照组40例;给予对照组单纯的多巴丝肼治疗,给予观察组多巴丝肼与小剂量的多奈哌齐联合治疗,对比两组患者认知功能和抑郁情况。结果:观察组治疗的总有效率显著高于对照组,差异具有统计学意义(P<0.05);比较两组患者治疗前后简易智力状态检查量表(MMSE)、汉密顿抑郁量表(HAMD)、蒙特利尔认知评估量表(Mo CA)评分,观察组患者比对照组改善更明显,差异具有统计学意义(P<0.05)。结论:临床治疗帕金森病可采用多巴丝肼与小剂量的多奈哌齐联合治疗,其疗效确切,能有效改善患者认知功能和抑郁情绪,提高患者生活质量。
Objective: To investigate the curative effect of dopas hydrazine combined with low dose of donepezil on Parkinson’s disease and its effect on cognitive function and depression. Methods: Eighty patients with Parkinson’s disease who were admitted from January 2014 to January 2017 in Yangjiang Hospital of Traditional Chinese Medicine were enrolled in this study. They were randomly divided into observation group (40 cases) and control group (40 cases). Control group Of dobesilazine treatment, given the observation group of dopas hydrazide and low-dose donepezil combination therapy, cognitive function and depression compared two groups of patients. Results: The total effective rate of observation group was significantly higher than that of control group, the difference was statistically significant (P <0.05). The MMSE, HAMD ), Montreal cognitive assessment scale (MoCA) score, the observation group patients improved more significantly than the control group, the difference was statistically significant (P <0.05). Conclusion: The clinical treatment of Parkinson’s disease can be treated with doppler’s hydrazine and low dose of donepezil. The curative effect is exact, which can effectively improve the cognitive function and depression of patients and improve the quality of life of patients.