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近些年由于基础医学对氧中间代谢的深入研究,已初步阐明临床长时间吸高浓度氧,特别是用于治疗新生儿窒息或呼吸衰竭时,可引起晶体后纤维增生症和支气管肺发育不良症的发病机理,已受到重视。氧之所以能引起组织细胞损害,是由于细胞膜主要通过脂类过氧化作用(Lipid peroxidation)受损,细胞本身则通过巯基(—SH)氧化作用受损。构成细胞膜的主要成分为脂蛋白,不同组织的细胞膜所含的磷脂成分亦各异。
In recent years, basic medicine on the oxygen metabolism in-depth study, has initially clarified the clinical long-term high concentration of oxygen, especially for the treatment of neonatal asphyxia or respiratory failure, can cause post-crystal fibroplasia and bronchopulmonary dysplasia The pathogenesis of disease, has been taken seriously. The reason why oxygen causes tissue cell damage is due to the cell membrane being damaged mainly by lipid peroxidation and the cells themselves being damaged by sulfhydryl (-SH) oxidation. The main component constituting the cell membrane lipoprotein, different tissues of the cell membrane contains phospholipid ingredients are also different.