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克隆氏病的病因未明。疾病活动期间,上皮细胞坏死和炎症导致绒毛变短、变厚和深部穿透性溃疡及线状裂沟。二胺氧化酶(DAO)是存在于小肠绒毛顶端细胞上的一种酶,在某些病变状态下,组织DAO活性降低。本研究目的是确定克隆氏病患者的肠DAO活性是否降低及其与组织学变化程度的关系。材料与方法:患者33例,男17人,女16人,年龄23～67岁。克隆氏病小肠组织标本15个,结肠组织标本9个,溃疡性结肠炎标本11例。正常小肠组织标本7个作对照。标本直径约1cm,取于肠切缘和其他病变部位。病理切片后,由病理科医师用单盲法作分析并明确诊断。组织学变化分为0～4级。正常组织为0级;固有膜轻微炎症和水肿为1级;隐窝炎症和脓肿形成、纤维化为2级;较严重的炎症有或无肉芽肿为3级;更严重
The etiology of Crohn’s disease is unknown. Epithelial cell necrosis and inflammation lead to shorter villi, thickened and deep penetrating ulcers and linear fissures during disease activity. Diamine oxidase (DAO) is an enzyme present on the cells of the tip of the intestinal villi and, in some lesion states, reduces tissue DAO activity. The aim of this study was to determine if bowel DAO activity was reduced in Crohn’s disease patients and its relationship to histological changes. Materials and Methods: 33 patients, 17 males and 16 females, aged 23 to 67 years. Crohn’s disease small intestine tissue specimens 15, colon tissue specimens 9, 11 cases of ulcerative colitis specimens. Normal small intestine tissue specimens 7 as a control. The specimen diameter of about 1cm, taken from the intestinal margin and other lesions. After biopsy, by pathologists using single-blind method for analysis and a clear diagnosis. Histological changes are divided into 0 to 4 levels. Normal tissue is grade 0; mild inflammation and edema of the lamina propria is grade 1; crypt inflammation and abscess formation, fibrosis grade 2; more severe inflammation with or without granuloma is grade 3; more serious