大环钴咪唑配合物的抗菌活性

• 作 者: 延玺 武延隽 朱守荣 林华宽 朱志昂 陈荣悌
• 机 构: 南开大学化学系!天津300071,南开大学化学系!天津300071,南开大学化学系!天津300071,南开大学化学系!天津300071,南开大学化学系!天津300071,南开大学化学系!天津30007
• 出 处: 中国药物化学杂志
• 发表日期: 1999年03期
• 关键词: 抗菌活性 金黄色葡萄球菌 配位数 抗菌实验 配位反应 化脓性球菌 外科手术 动物皮肤 氮杂环 抑制作用

Studies on the antibacterial activity of the product that cobalt(Ⅲ)complexes of 5,7,7,12,14,14 hexamethyl 1,4,8,11 tetra azacyclotetradeca 4,11 diene reacted with imidazole and metronidazolum were described.We found that the macrocyclic cobalt complex could react with imidazole,metronidazolum and formalized a new axial complex.Thermodynamic equilibrium constant of the reaction K and the thermodynamic parameter of the reaction Δ r H 0? 璵,Δ r S 0? 璵 were calculated by the spectroscopy method.The new macrocyclic cobalt imidazole complex could restrain growth of penicillin resistant Staphylococcus aureus.

Studies on the antibacterial activity of the product that cobalt (Ⅲ) complexes of 5,7,7,12,14,14 hexamethyl 1,4,8,11 tetra azacyclotetradeca 4,11 diene reacted with imidazole and metronidazolum were described.We found that the macrocyclic cobalt complex could react with imidazole, metronidazolum and formalized a new axial complex. Thermodynamic equilibrium constant of the reaction K and the thermodynamic parameter of the reaction Δ r H 0 玙, Δ r S 0 玙 were calculated by the spectroscopy method.The new macrocyclic cobalt imidazole complex could restrain growth of penicillin resistant Staphylococcus aureus.