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采用家犬灌胃２４周法，观察蝙蝠葛酚性碱（ＰＡＭＤ）２０ｍｇ／ｋｇ／ｄ、１００ｍｇ／ｋｇ／ｄ的不同剂量对犬肝肾功能、血常规及心电图的影响和停药后的恢复情况。研究结果表明：ＰＡＭＤ２０ｍｇ／ｋｇ／ｄ实验组犬总胆红素、谷丙转氨酶、碱性磷酸酶、谷草转氨酶、尿素氮、肌酐、血红蛋白、红细胞计数白细胞计数等与对照组比较无显著性差异（Ｐ＞０．０５）；１００ｍｇ／ｋｇ／ｄ实验组犬总胆红素、碱性磷酸酶及谷丙转氨酶值有所升高，且部分肝细胞出现脂肪样变，心电图与实验前比较有显著性差异（ｔ＝２．７５，Ｐ＜０．０５），Ｐ－Ｒ间期延长，提示本品高剂量对心肌传导有一定的延缓作用。停药后上述指标可恢复到正常水平
The effects of different dosages of PAMD 20mg / kg / d and 100mg / kg / d on liver and kidney function, blood routine and electrocardiogram and recovery after drug withdrawal Happening. The results showed that the total bilirubin, alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, urea nitrogen, creatinine, hemoglobin, red blood cell count and white blood cell count in 20 mg / kg / d PAMD group had no significant difference compared with the control group P> 0.05). The values of total bilirubin, alkaline phosphatase and alanine aminotransferase increased in 100 mg / kg / d experimental group, and some hepatocytes showed steatosis. The electrocardiogram was significantly higher than that before the experiment Sex difference (t = 2.75, P <0.05), prolonged P-R interval, suggesting that the high dose of this product has a certain delay in myocardial conduction. After stopping the above indicators can be restored to normal levels