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B7－1、B7－2是B7家族的两个重要成员，它们介导的共刺激信号诱导Th细胞分化为Th1和Th2细胞。Th1和Th2细胞分别分泌两种不同类型的细胞因子，它们在自身免疫性疾病的发生发展中起着非常重要的作用。CTLA4Ig通过封闭B7－1和B7－2调节Th细胞的分化方向，从而达到治疗自身免疫性疾病的作用。因而是一种很有前途的免疫调节药物。
B7-1 and B7-2, two important members of the B7 family, mediate the induction of costimulatory Th cells into Th1 and Th2 cells. Th1 and Th2 cells secrete two different types of cytokines, respectively, which play a very important role in the development of autoimmune diseases. CTLA4Ig regulates the differentiation direction of Th cells by blocking B7-1 and B7-2, so as to achieve the effect of treating autoimmune diseases. It is a promising immunomodulatory drug.