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本文将水溶性良好的凌甲基-β-CD(CM-β-CD)用于分离氯霉素中间体(CPM),考察了CM-β-CD作为毛细管电泳手性选择剂的分离性能。同时研究了pH值、CM-β-PCD浓度以及甲醇对分离的影响,并比较了CM-β-CD与β-CD分离CPM时的作用机理。
In this paper, chitosan (CPM) was prepared using chiral methyl-β-CD (CM-β-CD) with good water solubility. The separation performance of CM-β-CD as a chiral selector was studied. The effects of pH, concentration of CM-β-PCD and methanol on the separation were studied. The mechanism of action of CM-β-CD and β-CD on the separation of CPM was also studied.