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目的:介绍肠道内转运药物的主要膜转运蛋白,阐述口服药物经肠道转运机制,概括研究肠道药物转运体的主要研究方法。方法:查阅近几年的有关文献,进行整理和归纳。结果:肠道内药物转运体与药物在体内的吸收密切相关。结论:肠道中许多药物转运体参与了药物的吸收、分布、排泄及药物相互作用等,对药物的生物利用度有重要影响。明确其转运机制有利于提高药物的安全性和有效性,从而指导临床合理用药。
OBJECTIVE: To introduce the main membrane transporter of intestinal drug delivery, to elucidate the mechanism of oral drug transport through the intestine and to summarize the main research methods of intestinal drug transporter. Methods: consult the relevant literature in recent years, collated and summarized. Results: Intestinal drug transporter and drug absorption in the body are closely related. CONCLUSIONS: Many drug transporters in the intestine are involved in drug absorption, distribution, excretion, and drug interactions, which have important implications for the bioavailability of the drug. A clear mechanism of its transport is conducive to improving the safety and effectiveness of drugs to guide clinical rational use of drugs.