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目的 探讨青年期直肠癌的临床病理学特征 ,以提高其治疗水平。方法 回顾性分析 1975～ 2 0 0 1年收治的青年期直肠癌的发生部位、大体类型、组织学类型和淋巴结转移等病理学特征 ,并观察其预后。结果 青年期直肠癌占同期全部直肠癌的 6 2 % (15 8/ 2 5 3 8) ,1990年前后的比例分别为 10 2 %及 3 9% ,79 3 %位于腹膜返折以下 ,浸润型者占 75 9% ,粘液腺癌及低分化腺癌占 76 5 % ,侵犯浆膜者占 74 1% ,淋巴结转移者为64 6%。这些特点与壮老年直肠癌相比差异均具有非常显著性意义 (P <0 0 1)。青年期直肠癌的预后极差 ,五年生存率仅 2 1 5 % (3 4/ 15 8)。结论 青年期直肠癌有一系列不同于壮老年的临床病理学特征 ,预后差 ,其治疗水平有赖于提高对这些特征的认识 ,力争早期诊断及治疗
Objective To investigate the clinicopathological characteristics of adolescent rectal cancer in order to improve its therapeutic level. Methods The location, gross type, histological type and lymph node metastasis of adolescent rectal cancer admitted from 1975 to 2001 were analyzed retrospectively. The prognosis was also observed. Results The proportion of adolescent rectal cancer was 62% (15 8/2 858) of the total rectal cancer in the same period. The percentage of preoperative and postoperative rectal cancer was 10 2% and 39% respectively. 79 3% Accounting for 75.9%, mucinous adenocarcinoma and poorly differentiated adenocarcinoma accounting for 76.5%, serosal invasion accounted for 74.1%, and lymph node metastasis was 64.6%. These characteristics were significantly different from those of elderly patients with colorectal cancer (P <0.01). The prognosis of adolescent rectal cancer is very poor. The five-year survival rate is only 215% (34/158). Conclusions There are a series of clinicopathological features in adolescent rectal cancer that are different from those of older adults. The prognosis of adolescent rectal cancer is poor. The treatment depends on the improvement of understanding of these features and the early diagnosis and treatment