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目的分析加用格列美脲治疗单用胰岛素效果不佳2型糖尿病患者的临床效果。方法取昆山市第二人民医院收治的单用胰岛素治疗效果不佳的2型糖尿病患者作为研究对象,分别给予格列呲嗪控释片、格列美脲进行治疗,比较两组患者接受治疗后的FBG、PBG、HbA1c水平、胰岛素用量及低血糖发生率等情况差异。结果观察组患者接受治疗后1月及3月的各项糖尿病指标均明显优于对照组患者(P<0.05);接受治疗后1月,观察组与对照组患者的胰岛素用量无明显差异,观察组患者的低血糖发生率明显低于对照组患者(P<0.05);接受治疗后3月,观察组患者的胰岛素用量明显少于对照组患者(P<0.05),低血糖发生率明显低于对照组患者(P<0.05)。结论格列美脲可以有效改善患者对于胰岛素的抵抗,优化其血糖水平,同时避免低血糖的发生。
Objective To analyze the clinical effect of glimepiride in the treatment of type 2 diabetes patients with poor insulin. Methods Patients with type 2 diabetes mellitus who were treated with insulin alone in Second People’s Hospital of Kunshan City were treated with glibenclamide controlled-release tablets and glimepiride respectively. After two groups of patients were treated Of FBG, PBG, HbA1c levels, the amount of insulin and hypoglycemia incidence differences. Results The diabetic patients in the observation group were significantly better than those in the control group (P <0.05) after 1 and 3 months of treatment. There was no significant difference in the insulin dosage between the observation group and the control group after 1 month of treatment The incidence of hypoglycemia was significantly lower in the patients in the control group (P <0.05). After 3 months of treatment, the insulin dosage of the observation group was significantly less than that of the control group (P <0.05), and the incidence of hypoglycemia was significantly lower than that of the control group Control group patients (P <0.05). Conclusion glimepiride can effectively improve the patient’s resistance to insulin, optimize its blood glucose levels, and avoid the occurrence of hypoglycemia.