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目的 探讨一种无创 ,快速 ,高效便捷的监测膀胱肿瘤复发的方法用于肿瘤术后的随访。方法 采用标准ELISA法检测病人尿中的核基质蛋白 2 2 (NMP 2 2 )值 ,并对患者进行尿液膀胱肿瘤抗原 (BTAstat)测定 ,膀胱镜检及病理检测以明确有无肿瘤复发。结果 与膀胱镜检及活检结果相比较 ,尿的NMP 2 2检测可发现 76 7% (33/ 4 3)复发的病例 ,尿的BTAstat可发现 6 7 4 % (2 9/ 4 3)复发的病例。若将两项检测的结果综合考虑 ,则检测的准确率达 93 0 % (40 / 4 3)。结论 尿的NMP 2 2检测为一种快速 ,高效 ,便捷的监测膀胱肿瘤复发的方法 ,若同BTAStat检测联合使用 ,会提高其准确率 ,并可在术后随访中减低膀胱镜检的频率
Objective To explore a noninvasive, rapid, efficient and convenient method for monitoring the recurrence of bladder tumors for postoperative tumor follow-up. Methods The urinary NMP 2 2 in urine was detected by standard ELISA. The patients were examined with BTAstat, cystoscopy and pathological examination to find out whether tumor recurrence occurred. Results Compared with the results of cystoscopy and biopsy, urinary NMP 2 2 was found in 76 7% (33 of 4 3) recurrent cases and urinary BTAstat of 67 4% (2 9/43) recurrent Case. If the results of the two tests are taken into consideration, the accuracy of the test is 93% (40/43). Conclusion The urine NMP 2 2 test is a rapid, efficient and convenient method to monitor the recurrence of bladder cancer. If used in combination with the BTAStat test, its accuracy will be improved and the frequency of cystoscopy may be reduced at follow-up