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血管内皮细胞生长因子(VEGF)是最重要的刺激血管新生的细胞因子。VEGF的生物学效应是通过其特异性的膜受体即VEGF受体介导实现的。本文就VEGF及其受体的基因和蛋白结构、生物学作用、信号转导通路及在抗肿瘤血管新生治疗方面的研究进展作一综述。
Vascular endothelial growth factor (VEGF) is the most important cytokine that stimulates angiogenesis. The biological effects of VEGF are mediated through its specific membrane receptor, the VEGF receptor. This article reviews the research progress of VEGF and its receptor genes and protein structure, biological effects, signal transduction pathways and anti-angiogenesis therapy.