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将９０只昆明种小鼠随机等分为３组：Ⅰ组按每公斤体重３ｍｇ的剂量腹腔注射氯化镉溶液；Ⅱ组除注射同样剂量的氯化镉外，还以每公斤体重２ｍｇ的剂量腹腔注射亚硒酸钠溶液；Ⅲ组为对照，不作处理。药物注射每天１次，连续５ｄ。从注射后的第１、２、３、４、５周分别采血，检测ＲＢＣ－ＣＲ１和ＲＢＣ－ＩＣ花环率。结果表明，整个实验期间，Ⅰ组ＲＢＣ－ＣＲ１和ＲＢＣ－ＩＣ花环率均显著低于Ⅱ组和Ⅲ组（Ｐ＜０．０５或Ｐ＜０．０１），并有逐渐升高的趋势；Ⅱ组两种花环率逐渐降低。因此认为，镉会引起红细胞免疫功能的严重损伤，硒对其有明显的保护作用
Ninety Kunming mice were equally divided into three groups: Group I was treated intraperitoneally with 3 mg / kg body weight of cadmium chloride solution; Group II was injected with the same dose of cadmium chloride, Intraperitoneal injection of sodium selenite solution; Ⅲ group as a control, no treatment. Drug injection once a day for 5 days. Blood samples were taken from the 1st, 2nd, 3rd, 4th and 5th weeks after injection to detect the RBC-CR1 and RBC-IC rosette rate. The results showed that during the whole experiment period, the RBC-CR1 and RBC-IC rosette rate in group Ⅰ were significantly lower than those in group Ⅱ and group Ⅲ (P <0.05 or P <0.01), and gradually increased Group two rosette rate gradually decreased. So that, cadmium can cause severe damage to immune function of red blood cells, selenium has a significant protective effect