论文部分内容阅读
抗矽—14[4～(7氯化喹啉基—4哌哔嗪—1)丙烷磷酸盐],简称磷酸喹哌。与氯喹属同类药物。日本、西德曾有过用氯喹治疗实验性矽肺的报道,因毒性及副作用较大,故临床报告很少见到。国内上海医药工业研究院等单位,于1973年发现抗矽—14对大白鼠实验性矽肺具有治疗效果,而毒副作用远比氯喹为小,从而引起了有关科研单位的重视,在进行了大量实验研究工作后,过渡到临床试治观察。据第三次抗矽—14全国协作会议资料,进一步肯定了对实验性矽肺有抑制病变进展的疗效,在临床试用中,已有稳定病情,特别是个别病例X线胸片上肯定的团块状阴影缩小的报告。是一种治疗矽肺病有可喜苗头的新药。但最后结论性意见,有待全国抗矽—14鉴定会决定。
Anti-silicon -14 [4 ~ (7 quinolyl-4-piperazine-1) propane phosphate], referred to as quip phosphate. And chloroquine is a similar drug. Japan, West Germany have been reported with chloroquine treatment of experimental silicosis, due to greater toxicity and side effects, so rarely seen in clinical reports. Domestic Shanghai Institute of Pharmaceutical Industry and other units, found in 1973 anti-silicon -14 experimental silicosis in mice has a therapeutic effect, and side effects than chloroquine is small, which led to the attention of relevant scientific research units, conducted a large number of experiments After the research work, the transition to clinical trial observation. According to the third anti-silicon -14 national collaboration conference data further confirmed the experimental silicosis inhibit the progress of the disease in clinical trials, there has been a steady condition, especially in individual cases on the chest X-ray certainly block Shadow reduction report. It is a kind of new medicine to cure silicosis. However, the final conclusion, pending the national anti-silicon -14 appraisal will decide.