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(一)氯丙嗪用于治疗精神病已有20年的历史。虽然新的精神药物不断出现,但至今仍公认氯丙嗪是疗效高,且又安全的精神药物。在服用氯丙嗪短期内出现的所谓“急性”副作用,早已有不少的研究报告,而长期服用氯丙嗪后所出现的所谓“晚期”副作用的报告,只是在近几年才逐渐增多,主要是皮肤的色素沉着和眼部的改变,以及迟发性运动异常。A.C.Greiaer和K.Berry于1964年首先报告了长期大量服用氯丙嗪所引起的眼——皮肤综合征,在上千名服用氯丙嗪的慢性精神分裂症患者中有70个出现了皮肤暴露部分的特殊的色素沉着,其中49个较
(A) Chlorpromazine has been used for the treatment of mental illness for 20 years. Although new psychotropic substances continue to emerge, chlorpromazine is still recognized as a highly effective and safe psychotropic drug. There have been many reports of so-called “acute” side effects of short-term use of chlorpromazine, and the so-called “late” side effects of long-term use of chlorpromazine have only increased in recent years, Mainly skin pigmentation and eye changes, and delayed exercise disorders. ACGreiaer and K.Berry first reported ocular-skin syndrome caused by long-term use of chlorpromazine in high volume in 1964 and showed skin exposure in 70 of the thousands of patients with chronic schizophrenia taking chlorpromazine Part of the special pigmentation, of which 49 more