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作者提到氨苯砜可以治疗疱疹样皮炎与大疱性类天疱疮,也用于坏死性或变应性脉管炎等。这些疾病均伴有明显的多形核白细胞的浸润。其发病机理可能与免疫有关。因此提示在这些疾病的发病过程中 Arthus 样现象可能起了作用。在 Arthus 现象中抗体结合补体之后,多形核白细胞发生趋化性反应,释放出溶酶体酶,导致组织损伤。因此作者用以下试验来证明砜类药是否可以改变 Arthus 现象中的一个阶段。作者选择28个雄家兔。第一组8个家兔单用维生素甲50万单位,腹腔内注射8天。第二组8个家
The authors mentioned that dapsone can treat herpes-like dermatitis and bullous pemphigoid as well as necrotizing or allergic vasculitis. These diseases are accompanied by significant infiltration of polymorphonuclear leukocytes. Its pathogenesis may be related to immunity. This suggests that Arthus-like phenomena may play a role in the pathogenesis of these diseases. In the Arthus phenomenon, antibodies bind to complement, polymorphonuclear leukocytes undergo chemotactic responses, release lysosomal enzymes, and cause tissue damage. Therefore, the authors used the following test to prove whether sulfone drugs can change Arthus phenomenon in a stage. The author chooses 28 male rabbits. The first group of 8 rabbits with 500,000 units of vitamin A alone, intraperitoneal injection of 8 days. The second group of 8 home