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人粒细胞无形体病(HGA)是由嗜吞噬细胞无形体引起的一类人兽共患病,可经蜱叮咬的方式传播到人和动物体内,也可通过人-人的院内传播途径传播。1994年,美国首次报道威斯康星州一名患者感染HGA,随后该病呈世界性分布,在美洲、欧洲、澳洲、非洲及亚洲均有感染报道,目前已发展成为美国及欧洲第三大常见的媒介传播感染疾病。2006年,我国诊断出首例HGA,随后其感染逐年上升且分布广泛。以发热伴白细胞、血小板减少和多脏器功能损害为主要特点,该病无非常特异的临床症状,容易误诊,致使治疗不当导致病情恶化,甚至死亡,对我国人畜的健康构成极大的威胁。因此,对HGA的早期确诊对该病的有效治疗有着重要意义,其临床诊断需综合考虑流行病学、临床表现及实验室检查,治疗首选强力霉素。
Human granulocytic anamorphosis (HGA) is a group of zoonoses caused by phagocyte-like in phagocytes that can be transmitted to humans and animals via tick bites and also to human-human in-hospital transmission . In 1994, the United States reported for the first time a patient infected with HGA in Wisconsin. The disease was then globally distributed and reported in the Americas, Europe, Australia, Africa and Asia, and has now become the third most common medium in the United States and Europe Transmission of infectious diseases. In 2006, our country diagnosed the first case of HGA, then its infection increased year by year and widely distributed. To fever with leucocytes, thrombocytopenia and multiple organ dysfunction as the main feature of the disease is not very specific clinical symptoms, easy misdiagnosis, resulting in improper treatment led to the deterioration of the disease, and even death, pose a great threat to the health of our people and animals. Therefore, the early diagnosis of HGA for the effective treatment of the disease is of great significance, its clinical diagnosis should be comprehensive consideration of epidemiology, clinical manifestations and laboratory tests, the preferred treatment of doxycycline.