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目的评价澄迈县乙型肝炎病毒母婴阻断策略的实施效果。方法利用妇幼保健信息系统收集横断面资料;对全县2014年10月1日至2015年9月30日期间住院分娩的完全采取阻断策略的HBs Ag阳性产妇及其分娩的8~12月龄婴儿进行采血,使用乙肝病毒标志物-胶体金法检测乙肝病毒标志物。结果全部157例母婴样本中,婴儿HBs Ag阳性率为2.5%(4例),母婴阻断成功率为97.5%,婴儿HBs Ab阳性率为69.5%(109例),婴儿乙肝病毒标志物检测全为阴性率为28.0%(44例),4例HBs Ag阳性婴儿的母亲HBs Ag和HBe Ag均为阳性,与单纯HBs Ag阳性母亲相比差异有统计学意义(P=0.019)。结论澄迈县乙型肝炎病毒母婴阻断策略落实到位,有效的阻断乙肝病毒母婴传播的风险。在现行母婴阻断策略下,更应关注HBs Ag和HBe Ag均为阳性孕产妇的母婴阻断防控和婴儿免疫无应答情况的改善。
Objective To evaluate the implementation effect of blocking strategy of hepatitis B virus in mother and infant in Chengmai county. Methods The maternal and child health information system was used to collect cross-sectional data. The HBsAg-positive mothers and their 8-8-month-old mothers with complete block strategy in hospital delivery from October 1, 2014 to September 30, 2015 were enrolled in this study. Blood samples were taken from infants and hepatitis B virus markers were detected using the gold colloidal gold assay. Results The positive rate of HBs Ag in infants was 2.5% (4 cases), the success rate of maternal and child occlusion was 97.5%, the positive rate of HBs Ab in infants was 69.5% (109 cases), and the infant hepatitis B virus markers The detection rate was 28.0% (44 cases). HBs Ag and HBe Ag were positive in all 4 HBsAg positive infants, which was significantly different from that of HBs Ag positive mothers (P = 0.019). Conclusion Chengmai hepatitis B virus maternal and child block strategy put in place, effectively blocking the risk of mother-to-child transmission of hepatitis B virus. In the current mother-and-child strategy, more attention should be paid to the prevention and control of maternal-child interruption and the improvement of infant’s immune non-responsiveness in HBsAg and HBeAg-positive pregnant women.