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目的探讨血清胱抑素C(Cys C)在大肠癌患者的表达和临床意义。方法采集广州某三甲医院住院期间治疗的大肠癌患者静脉血78份,其中未转移组45份和转移组33份,离心分离血清,采用日本日立有限公司7600全自动生化分析仪检测血清Cys C的水平并进行分析。结果大肠癌未转移组和转移组血清Cys C分别为(1.36±0.88)mg/L和(1.37±0.71)mg/L,均明显高于正常对照组(0.78±0.10)mg/L,差异均具有统计学意义(P<0.05);大肠癌未转移组、转移组以及正常对照组的高年龄段(61~90岁)血清Cys C水平均相应高于低年龄段(31~60岁),差异均具有统计学意义(P<0.05);未转移组以及转移组接受大肠肿瘤切除手术和辅助化疗7 d后,血清Cys C水平分别为(1.07±0.37)mg/L与(1.04±0.49)mg/L,相对于切除手术之前均有所降低,差异均具有统计学意义(P<0.05)。结论血清胱抑素C在大肠癌患者接受手术前中升高,手术和辅助化疗后降低,作为肿瘤辅助诊断指标具有一定的临床价值。
Objective To investigate the expression and clinical significance of serum cystatin C (Cys C) in patients with colorectal cancer. Methods 78 patients with colorectal cancer who were treated during hospitalization in Guangzhou were enrolled. Among them, 45 were non-metastasis group and 33 were metastasis group. The serum was separated by centrifugation and the serum Cys C was detected by a 7600 automatic biochemical analyzer from Hitachi, Ltd. Level and analyze. Results The serum levels of Cys C were (1.36 ± 0.88) mg / L and (1.37 ± 0.71) mg / L respectively in the non-metastasis group and the metastasis group, which were significantly higher than those in the normal control group (0.78 ± 0.10) mg / L (P <0.05). The levels of serum Cys C in high-metastasis group (61-90 years old), non-metastasis group, metastasis group and normal control group were higher than those in lower age group (31-60 years) (1.07 ± 0.37) mg / L and (1.04 ± 0.49), respectively, in the non-metastasis group and the metastasis group after 7 days of colorectal tumor resection and adjuvant chemotherapy. The difference was statistically significant (P <0.05) mg / L, compared with that before resection, the difference was statistically significant (P <0.05). Conclusions Serum cystatin C is elevated in patients with colorectal cancer before surgery and decreases after surgery and adjuvant chemotherapy. It has certain clinical value as a diagnostic indicator of tumor.