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目的 研究缺血预处理和缺血后处理对兔心收缩功能和心肌梗死范围的影响 ,探讨在体条件下 ,缺血后处理是否具有减轻缺血心肌再灌注损伤的作用 .方法 采用兔缺血再灌注模型 ,分别以缺血前短暂心肌缺血作预处理 ,或缺血后再灌前 ,多次短暂再灌停灌作缺血后处理 .以多导生理仪监测和记录血流动力学指标 ,TTC法确定心肌梗死范围 .结果 缺血预处理组及缺血后处理组心肌梗死范围分别为 (14.7±6 .0 ) %和 (12 .5± 5 .4) % ,均低于对照组 (2 6 .7± 6 .7) % (P<0 .0 1) ,兔左室内压峰值 (L VSP)恢复率和 dp/dtmax恢复率均高于对照组 ,再灌注心律失常发生率明显低于对照组 (P<0 .0 5 ) .结论 缺血后处理与缺血预处理对缺血心脏具有相似的保护作用 ,可改善缺血 -再灌心脏收缩功能 ,缩小心肌梗死范围
Objective To investigate the effects of ischemic preconditioning and ischemic postconditioning on the cardiac contractile function and infarct size in rabbits and to explore whether ischemic postconditioning can reduce the myocardial ischemia reperfusion injury in vivo.Methods Rabbit ischemia Reperfusion model, respectively, pre-ischemic myocardial ischemia for pretreatment, or reperfusion after ischemia, repeated short-term reperfusion irrigation for ischemic postconditioning.Multi-guide physiology instrument to monitor and record hemodynamics Index and TTC method were used to determine the extent of myocardial infarction.Results The ranges of myocardial infarction in ischemic preconditioning group and ischemic postconditioning group were (14.7 ± 6 .0)% and (12.5 ± 5.4)%, respectively, The recovery rate of left ventricular pressure peak (L VSP) and dp / dtmax in rabbits in control group were significantly higher than those in control group (26.7 ± 6.7%) (P <0.01), and the incidence of reperfusion arrhythmia (P0.05) .Conclusion Ischemic postconditioning and ischemic preconditioning have similar protective effect on ischemic heart, which can improve the systolic function of ischemia-reperfusion heart and reduce the range of myocardial infarction