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对服用 3种补肾助孕方药的临床排卵障碍性不孕者 ,分别于服药前和服药后的LH -2、LH +7、LH +10进行子宫内膜组织活检取材 ,采用自身对照方法观察内膜组织形态学表现 ,VEGF、TGF、LIF、bFGF/FGF共 4种血管生成因子和VEGFR、EGFR、TGFR、CD10 5、PDGFR -α共 5种血管生成因子受体的变化。结果表明 ,3种方药对人子宫内膜组织的血管生成活性和作用均具有强烈的正向促进作用 ,组织中具有旺盛的血管生成表现 ,除TGF和TGFR外其它 7种因子的表达强度均明显增强。说明补肾助孕中药具有明确的促血管生成作用。
For patients with clinical anovulatory infertility who took 3 kinds of Bushen Zhuyun Prescriptions, LH-2, LH+7, and LH+10 before and after medication were collected for endometrial biopsy and observed by self-control method. Membrane morphology, VEGF, TGF, LIF, bFGF / FGF four angiogenic factors and VEGFR, EGFR, TGFR, CD10 5, PDGFR-α a total of five kinds of angiogenic factor receptor changes. The results showed that the three kinds of prescriptions have a strong positive effect on the angiogenesis activity and effect of human endometrial tissue. The tissue has a strong angiogenic performance, and the expression intensity of other seven factors besides TGF and TGFR are obvious. Enhanced. It shows that the kidney-enhancing and gestational Chinese medicine has a clear angiogenic effect.