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肺炎克雷伯菌是院内感染的常见条件致病菌。近年来，随着肺炎克雷伯菌所致肝脓肿患者的发病数不断增加，高毒力肺炎克雷伯菌引起广泛关注。高毒力肺炎克雷伯菌具有高黏液表型和高毒力的特征，可引起免疫力正常的患者发生重症社区获得性感染，如肝脓肿、肺炎、化脓性眼内炎及化脓性脑膜炎等。本文对高毒力肺炎克雷伯菌的流行病学及毒力因子的研究进展作一综述。“,”Klebsiella pneumoniae is a common hospital-acquired pathogen. In recent years, patients with liver abscess caused by n Klebsiella pneumoniae have gradually increased, and hypervirulent n Klebsiella pneumoniae (hvKP) has caused widespread concern. hvKP which is characterized by high mucinous and high virulence, is easy to cause severe community acquired infections among healthy individuals, such as liver abscess, pneumonia, suppurative endophthalmitis and suppurative meningitis. The advances on the epidemiological characteristics and virulence factors of hvKP are reviewed in this articles.n