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在肝硬化患者,消化性溃疡的并发率很高.虽有多种解释,许多问题尚未解决.本文对24例肝硬化患者根据肝功能受损程度研究其胃酸分泌、胃粘膜损伤的发病率及血浆胃泌素和GIP(肠抑胃肽)的变化,以阐明肝摄取肠道激素的程度,血浆胃泌素及GIP与酸分泌的关系.材料和方法:24例坏死后和酒精性肝硬化患者,男16名,女8名,平均年龄53岁,年龄范围37～70岁.禁食一夜,用16-French双腔鼻胃管插入胃底区域,尽可能抽去胃内容后,收集胃液15分钟,连续2次.然后肌注四肽胃泌素(4μg/kg),抽取胃液5次,每次间隔15分钟.分别测定基础酸分泌量(BAO)、最高酸分泌量(MAO)和高峰酸分泌量(PAO).另一天,18例患者禁食一夜后进300g米粥和一个鸡蛋(碳水化合物70.9%,蛋白16.4%和脂肪10.7%)的试验餐.在餐前与餐后15’、30’、60’、90’、及120’取血标本,冰置待测,并作吲哚氰绿清除试验(ICG_k以mEq/h表示).另以13例无肝病、溃疡病或糖尿病的住院患者作为对照.结果:1.胃粘膜损伤:经胃镜检查,10例肝硬化发
In patients with cirrhosis, the incidence of peptic ulcer is very high, although there are many explanations, many problems remain unresolved.In this paper, 24 patients with liver cirrhosis according to the degree of liver damage to study the gastric acid secretion, the incidence of gastric mucosal injury and Plasma gastrin and GIP (gastrointestinal inhibitory peptide) changes in order to clarify the extent of hepatic uptake of intestinal hormones, plasma gastrin and GIP and acid secretion.Materials and Methods: 24 cases of post-necrotic and alcoholic cirrhosis Patients, 16 males and 8 females, mean age 53 years old, aged 37 to 70. Fasting overnight, with 16-French double nasogastric tube inserted into the fundal region, as far as possible after pumping stomach contents, collecting gastric juice 15 minutes, two times in a row, then intramuscular injection of tetrapeptide gastrin (4μg / kg), gastric juice 5 times, each time interval of 15 minutes.Determination of basal acid secretion (BAO), maximum acid secretion (MAO) and Peak acid secretion (PAO) .On the other day, 18 patients were fasted overnight with 300 g rice porridge and one egg (carbohydrate 70.9%, protein 16.4% and fat 10.7%) in the test meal. , 30 ’, 60’, 90 ’and 120’ blood samples were taken and tested in ice, and indocyanine green clearance test (ICG_k in mEq / h) Disease, hospitalized patients or diabetic ulcer disease as a result of comparison: 1. gastric mucosal injury: by endoscopy, 10 cases of cirrhosis of the liver fat