【摘 要】
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Dear Editor,Tailed, double-stranded DNA (dsDNA) bacteriophages,which belong to the order of Caudovirales, have a tail attached to a pentameric vertex of the ico
【机 构】
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Key Laboratory for Matter Microstructure and Function of Hunan Province, Key Laboratory of Low-dimen
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Dear Editor,Tailed, double-stranded DNA (dsDNA) bacteriophages,which belong to the order of Caudovirales, have a tail attached to a pentameric vertex of the icosahedral capsid shell (head) through a 12-fold portal (Johnson and Chiu,2007).The phages package genomic dsDNA into a round procapsid using the portal in complex with an ATP-dependent terminase complex as the motor.During packaging, the procapsid shell expands to a more angular intermediate to match the size of the viral genome (Guo et al., 2014).When the phage head is full, the portal detects inteal pressure and conveys a signal from the inner capsid to the exterior,which triggers a sequence of events—the terminase complex cleaving mature DNA genome from a multi-genome concatemer, the release of the terminase complex from the portal, and the attachment of the tail complex—in the completion of phage assembly (Lander et al., 2006;Johnson and Chiu, 2007).At the beginning of phage infection, the tail is responsible for receptor recognition, and the portal and tail act as a tunnel for DNA delivery into the host cytoplasm (Johnson and Chiu, 2007).These mechanisms of DNA packaging and ejection may also be conserved in many other DNA viruses, including herpesvirus (Wang et al., 2020;Yang et al., 2020).
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