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With great interest we have read the study of Liu et al.(2018) revealing the role of RNA binding protein 24 (RBM24) on global alteative splicing and dilated cardiomyopathy (DCM) in mice.As suggested previously,deficiency of Rbm24 causes embryonic lethality limiting the functional analyses (Yang et al.,2014).To circumvent this limitation the authors generated cardiac specific Rbm24 deficient mice and showed that homozygous deletion of Rbm24 at postnatal stage leads to rapidly progressive DCM and heart failure (Liu et al.,2018).