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本文对在在启东、泰兴原发性肝细胞癌（ＨＣＣ）高发区随机抽取的１４０份ＨＣＣ病例和２４７份对照资料，进行了乙型肝炎病毒（ＨＢＶ）、丙型肝炎病毒（ＨＣＶ）感染与ＨＣＣ关系的病因学研究。结果显示：病例ＨＢＶ总感染指标和抗－ＨＣＶ的ＯＲ值为４．６７，多元非条件Ｌｏｇｉｓｔｉｃ回归分析显示：在ＨＢＶ感染指标中，以ＨＢｓＡｇ，抗－ＨＢｃ和前Ｓ２蛋白３指标的意义较大，均入选多元模型，抗－ＨＣＶ也作为ＨＣＶ感染的唯一指标入选多元模型Ａ，且两模型的拟合较满意，说明两者的感染均对ＨＣＣ的发生有一定的病因学作用，ＨＢＶ和ＨＣＶ混合感染的ＯＲ值为７．８４２，约等于两者分别感染的ＯＲ值之积，说明两者之间有一定的协同作用。ＰＡＲ指标的分析表明，ＨＢＶ和ＨＣＶ的综合ＰＡＲ值在７３．６４％～７５．１１％之间，抗－ＨＣＶ的ＰＡＲ值为１１．４６％，即如能有效控制人群ＨＢＶ和ＨＣＶ的感染率，将使该地ＨＣＣ的发病数减少７５％左右，其中由ＨＣＶ感染引起的ＨＣＣ病例约占１１．４６％，说明该地ＨＢＶ的感染仍为ＨＣＣ的主要病因因素，ＨＣＶ感染的病因作用次之。
In this paper, hepatitis B virus (HBV) and Hepatitis C virus (HCV) infections were performed in 140 HCC cases and 247 control samples randomly selected from high incidence areas of primary hepatocellular carcinoma (HCC) in Qidong and Taixing. Etiology study of HCC relationship. The results showed that the total HBV infection index and the anti-HCV OR were 4.67. Multivariate non-conditional Logistic regression analysis showed that the significance of HBsAg, anti-HBc and pre-S2 protein 3 was significant in the HBV infection index. All of them were included in the multivariate model. Anti-HCV was also selected as the only indicator of HCV infection in the multivariate model A. The fitting of the two models was satisfactory, indicating that both infections had a certain etiological role in the occurrence of HCC, HBV and HCV The OR value of the mixed infection was 7.842, which was approximately equal to the product of the OR of the two infections, indicating a certain synergy between the two. The analysis of PAR indicators showed that the combined PAR values of HBV and HCV were between 73.64% and 75.11%, and the PAR value of anti-HCV was 11.46%. This means that the HBV and HCV infection rates can be effectively controlled in the population. The incidence of HCC in this area will be reduced by about 75%, of which HCC cases caused by HCV infection account for about 11.46%, indicating that HBV infection in this area is still the main cause of HCC, and the etiology of HCV infection is the second most important factor. .