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氨基糖苷类抗菌药在治疗严重细菌感染,尤其是革兰阴性杆菌感染中发挥着重要的作用。鲍曼不动杆菌16SrRNA甲基化酶是近年来发现的一种新的耐药决定因子,介导对多种氨基糖苷类高水平耐药。目前在革兰阴性菌中已发现7种16SrRNA甲基化酶基因(armA、rmtA、rmtB、rmtC、rmtD、rmtE和npmA),鲍曼不动杆菌中仅发现armA。此类基因常位于质粒、Ⅰ类整合子或转座子上,引起耐药机制的传播。
Aminoglycoside antibacterials play an important role in the treatment of severe bacterial infections, especially gram-negative bacilli. Acinetobacter baumannii 16SrRNA methylase is a new resistance determinant discovered in recent years, which mediates high levels of resistance to a variety of aminoglycosides. Seven 16SrRNA methylase genes (armA, rmtA, rmtB, rmtC, rmtD, rmtE and npmA) have been found in Gram-negative bacteria and only armA is found in Acinetobacter baumannii. Such genes are often located in plasmids, class I integrons or transposons, causing the spread of resistance mechanisms.