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目的 :研究抑癌基因P1 6在胃癌中的表达 ,探讨P1 6蛋白在胃癌浸润转移中的作用。方法 :采用链霉菌抗生物素蛋白过氧化物酶连接法 (SP法 ) ,检测 46例胃癌组织中P1 6蛋白的表达。结果 :P1 6表达与性别、年龄、浸润深度无显著意义 (P >0 .0 5) ;伴淋巴结转移胃癌P1 6蛋白表达阳性率为 6.9% ,无淋巴结转移胃癌为 35.3% ,差异有显著意义 (P <0 .0 5)。结论 :P1 6蛋白表达缺失可能与胃癌转移有关。
Objective: To study the expression of tumor suppressor gene P16 in gastric cancer and to explore the role of P16 protein in the invasion and metastasis of gastric cancer. Methods : The expression of P16 protein in 46 gastric cancer tissues was detected by streptavidin peroxidase ligation (SP method). RESULTS: There was no significant difference in the expression of P16 with gender, age, and depth of invasion (P > 0.05). The positive rate of P16 protein expression in gastric cancer with lymph node metastasis was 6.9%. The rate of gastric cancer without lymph node metastasis was 35.3%. The difference was significant. (P <0. 0 5). Conclusion : The loss of P16 protein expression may be related to the metastasis of gastric cancer.