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人的机体随着年龄增长可发生生理和病理变化,因而老年人各器官和酶系统的退化,可导致对药物效应的改变~([1][2])。任何药物要引起某种效应,都必须经历三个主要过程:(1)给药到药物溶解,使药物处于可吸收状态(药剂学过程);(2)药物的吸收、分布、代谢和排泄,使药物在血中产生一定的浓度,以及药物或其代谢产物最终由体内排出等(药代学过程);(3)药物以一定有效浓度进入作用部位,并与机体某种成
The human body can undergo physiological and pathological changes as it ages, and the degradation of various organs and enzyme systems in the elderly can lead to a change in the drug’s effect. [1] [2]). There are three main processes that any drug must exert to cause an effect: (1) administration to dissolution of the drug, rendering the drug in an absorbable state (pharmacological process); (2) absorption, distribution, metabolism and excretion of the drug, So that drugs in the blood to produce a certain concentration, and the drug or its metabolites eventually discharged from the body, etc. (pharmacokinetics); (3) the drug to a certain effective concentration into the site of action, and the body of a