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目的:探讨在冠心病患者中,阿司匹林的个体差异及相关因素。方法:稳定型心绞痛患者100例,服拜阿司匹林100 mg/d,7 d后测定血栓素B2(TXB2)、6-酮-前列腺素F1α(6-keto-PGF1α)、D-二聚体(D-D)、纤维蛋白原(FIB)、同型半胱氨酸(HCY)及C反应蛋白(CRP)水平,同时使用血栓弹力仪测定血小板的反应性,并根据反应性不同将患者分为四分位组(高反应性组和低反应性组),观察两组患者的临床特征。结果:血小板反应性呈正态分布;高反应性的患者中女性(52%vs.28%,P<0.05)及糖尿病患者(64%vs.32%,P<0.05)的比例较高;血栓前状态标记物中TXB2[(102±17)ng/Lvs.(74±17)ng/L,P<0.05]及CRP[(7.7±1.6)mg/Lvs.(4.3±1.2)mg/L,P<0.05]在血小板高反应性的患者中高于低反应性组。结论:冠心病患者血小板反应性存在个体差异。
Objective: To investigate the individual differences and related factors of aspirin in patients with coronary heart disease. Methods: One hundred patients with stable angina pectoris were treated with aspirin 100 mg / d, and the levels of TXB2, 6-keto-PGF1α and D-dimer were measured after 7 days. ), Fibrinogen (FIB), homocysteine (HCY) and C-reactive protein (CRP) were detected by ELISA. The platelet reactivity was measured by thromboelastometry and divided into quartiles (Highly reactive group and low reactivity group), the clinical features of two groups were observed. Results: The platelet reactivity was normally distributed. The proportion of women with high reactivity (52% vs.28%, P <0.05) and diabetic patients (64% vs.32%, P <0.05) TXB2 [(102 ± 17) ng / L vs (74 ± 17) ng / L, P <0.05] and CRP [(7.7 ± 1.6) mg / L vs (4.3 ± 1.2) mg / P <0.05] was higher in patients with platelet hyperreactivity than in patients with low reactivity. Conclusion: There are individual differences in platelet reactivity in patients with coronary heart disease.