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探讨神经内分泌 G、D细胞与慢性胃炎的关系。用免疫细胞化学方法对 5 2例慢性胃炎及 9例对照者进行胃窦粘膜内 G、D细胞密度计数。结果显示慢性胃炎病人的 G、 D细胞数均低于对照组 ,特别是萎缩性胃炎 G、 D细胞显著减少 ,同时还发现不同组别、不同程度的萎缩性胃炎 ,其 G细胞的数量均大于 D细胞 ,G/ D细胞的比值在中、重度萎缩性胃炎与其它组相比有显著性差异 (P<0 .0 1)。资料还显示 G、D细胞的计数不仅可以判断胃窦粘膜的萎缩程度 ,而且可作为观察临床疗效的一项重要指标。
To investigate the relationship between neuroendocrine G and D cells and chronic gastritis. Fifty-two patients with chronic gastritis and 9 controls were immunocytochemically counted for G and D cell density in the antral mucosa. The results showed that patients with chronic gastritis G, D cells were lower than the control group, especially atrophic gastritis G, D cells was significantly reduced, but also found in different groups, varying degrees of atrophic gastritis, the number of G cells were greater than D cells, G / D ratio in the medium and severe atrophic gastritis compared with other groups were significantly different (P <0.01). The data also show that the counts of G and D cells can not only judge the atrophy degree of gastric mucosa, but also can be used as an important index to observe clinical curative effect.